Typhus is a bacterial disease that can be spread from some animals to humans by fleas. A more serious kind of typhus that is spread by lice, called louse-borne or epidemic typhus, is not usually observed in the United States. Flea-borne typhus, also called murine or endemic typhus, is a disease caused by the bacteria Rickettsia typhi. Another similar organism, Rickettsia felis is thought to cause endemic typhus.